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CHCHD3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - CHCHD3 Antibody (Center) AW5353-U100
    All lanes : Anti-CHCHD3 Antibody (Center)(AW5353) at 1/1000 dilution Lane 1: 293T whole cell lysates Lane 2: A431 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9NX63
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW H=26 KDa
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 54927
Antigen Region 83-116 aa
Other Names Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial, CHCHD3, MINOS3
Dilution WB~~1:1000
Target/Specificity This CHCHD3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 83-116 amino acids from the Central region of human CHCHD3.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHCHD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHCHD3
Synonyms MIC19, MINOS3
Function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CRB9}; Lipid-anchor; Intermembrane side {ECO:0000250|UniProtKB:Q9CRB9}. Cytoplasm. Nucleus Mitochondrion
Tissue Location Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.
Research Areas
Citations (0)
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Background

Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Choudhary C.,et al.Science 325:834-840(2009).

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$ 370.00
Cat# AW5353-U100
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