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PNP Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P00491 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | H=32;M=32;Rat=32 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 4860 |
|---|---|
| Antigen Region | 145-178 aa |
| Other Names | Purine nucleoside phosphorylase, PNP, Inosine phosphorylase, Inosine-guanosine phosphorylase, PNP, NP |
| Dilution | WB~~1:1000 |
| Target/Specificity | This PNP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-178 amino acids from the Central region of human PNP. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PNP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PNP |
|---|---|
| Synonyms | NP |
| Function | Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
References
Williams S.R.,et al.Nucleic Acids Res. 12:5779-5787(1984).
Williams S.R.,et al.J. Biol. Chem. 262:2332-2338(1987).
Yu L.,et al.Environ. Health Perspect. 111:1421-1427(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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