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TIMM50 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q3ZCQ8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | H=40,50 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 92609 |
|---|---|
| Antigen Region | 25-56 aa |
| Other Names | Mitochondrial import inner membrane translocase subunit TIM50, TIMM50, TIM50 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This TIMM50 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 25-56 amino acids from the N-terminal region of human TIMM50. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TIMM50 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIMM50 |
|---|---|
| Synonyms | TIM50 |
| Function | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.
References
Guo Y.,et al.J. Biol. Chem. 279:24813-24825(2004).
Zheng H.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Zhang C.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
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