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ALDH6A1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, WB |
|---|---|
| Primary Accession | Q02252 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | H=58;M=58 KDa |
| Isotype | IgG1,κ |
| Antigen Source | HUMAN |
| Gene ID | 4329 |
|---|---|
| Antigen Region | 104-523 aa |
| Other Names | ALDH6A1; MMSDH; Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Aldehyde dehydrogenase family 6 member A1 |
| Dilution | IF~~1:25 WB~~1:1000 IHC-P~~1:25 |
| Target/Specificity | This ALDH6A1 antibody is generated from mouse immunized with ALDH6A1 recombinant protein. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALDH6A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDH6A1 (HGNC:7179) |
|---|---|
| Function | Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine. |
| Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.
Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34. Kuiper H, et al. Cytogenet Genome Res, 2005. PMID 15909363.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
The human plasma proteome: a nonredundant list developed by combination of four separate sources. Anderson NL, et al. Mol Cell Proteomics, 2004 Apr. PMID 14718574.
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