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CLIC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O00299 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=27 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 1192 |
|---|---|
| Antigen Region | 136-166 aa |
| Other Names | CLIC1;Chloride intracellular channel protein 1 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This CLIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-166 amino acids from the Central region of human CLIC1. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLIC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLIC1 {ECO:0000303|PubMed:16339885, ECO:0000312|HGNC:HGNC:2062} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox- regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. |
| Cellular Location | Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6MG61}. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:12681486, PubMed:9139710). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11551966, PubMed:11940526, PubMed:12681486, PubMed:14613939, PubMed:9139710). Might not be present in the nucleus of cardiac cells (By similarity) {ECO:0000250|UniProtKB:Q6MG61, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710} |
| Tissue Location | Expression is prominent in heart, placenta, liver, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
References
Xie T., et al. Genome Res. 13:2621-2636(2003).
Shiina S., et al. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Valenzuela S.M., et al. J. Biol. Chem. 272:12575-12582(1997).
Noh Y.H., et al. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Chuang J.Z., et al. J. Neurosci. 19:2919-2928(1999).
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