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BLMH Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q13867 |
| Other Accession | P70645, P13019, Q8R016 |
| Reactivity | Human, Mouse |
| Predicted | Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=53;M=53;Rat=52 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | Human |
| Gene ID | 642 |
|---|---|
| Antigen Region | 212-242 aa |
| Other Names | BLMH;Bleomycin hydrolase |
| Dilution | IF~~1:25 WB~~1:1000 |
| Target/Specificity | This BLMH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-242 amino acids from the Central region of human BLMH. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BLMH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BLMH |
|---|---|
| Function | The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. |
| Cellular Location | Cytoplasm. Cytoplasmic granule. Note=Co-localizes with NUDT12 in the cytoplasmic granules. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity).
References
Barrow I.K.-P., et al. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Ferrando A.A., et al. Cancer Res. 56:1746-1750(1996).
Broemme D., et al. Biochemistry 35:6706-6714(1996).
Kalnine N., et al. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
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