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TSN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, IHC-P, WB |
|---|---|
| Primary Accession | Q15631 |
| Other Accession | Q62348, P97891, Q08DM8, NP_004613.1 |
| Reactivity | Human |
| Predicted | Bovine, Hamster, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=26;M=26 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 7247 |
|---|---|
| Antigen Region | 109-138 aa |
| Other Names | TSN; Translin; Component 3 of promoter of RISC |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 |
| Target/Specificity | This TSN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human TSN. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSN |
|---|---|
| Function | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. |
| Cellular Location | Cytoplasm. Nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.
References
Chiaruttini, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16481-16486(2009)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Sengupta, K., et al. Biochemistry 45(3):861-870(2006)
Kaluzhny, D., et al. J. Biomol. Struct. Dyn. 23(3):257-265(2005)
Gupta, G.D., et al. FEBS Lett. 579(14):3141-3146(2005)
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