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PMM2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O15305 |
| Other Accession | Q9Z2M7, Q60HD6, Q3SZJ9, NP_000294.1 |
| Reactivity | Human |
| Predicted | Mouse, Monkey, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28082 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 5373 |
|---|---|
| Antigen Region | 198-226 aa |
| Other Names | PMM2; Phosphomannomutase 2 |
| Dilution | WB~~1:2000 |
| Target/Specificity | This PMM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human PMM2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PMM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PMM2 |
|---|---|
| Function | Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq].
References
Vega, A.I., et al. Hum. Mutat. 30(5):795-803(2009)
Coman, D., et al. Am. J. Med. Genet. A 146(3):389-392(2008)
Vermeer, S., et al. J. Neurol. 254(10):1356-1358(2007)
Coman, D., et al. J Clin Neurosci 14(7):668-672(2007)
Schollen, E., et al. Mol. Genet. Metab. 90(4):408-413(2007)
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