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Mouse Camkk2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8C078 |
| Other Accession | NP_663333.1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=65;M=65;Rat=64 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | MOUSE |
| Gene ID | 207565 |
|---|---|
| Antigen Region | 43-71 aa |
| Other Names | Camkk2; Kiaa0787; Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase kinase beta |
| Dilution | WB~~1:1000 |
| Target/Specificity | This Mouse Camkk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-71 amino acids from the N-terminal region of mouse Camkk2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Camkk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Camkk2 |
|---|---|
| Synonyms | Kiaa0787 |
| Function | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching (By similarity). May be involved in hippocampal activation of CREB1. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q96RR4}. Cytoplasm {ECO:0000250|UniProtKB:Q96RR4}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96RR4}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000250|UniProtKB:Q96RR4} |
| Tissue Location | Expressed in all tissues tested. A differential expression pattern compared to CAMKK1 is observed in the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1.
References
Jin, X.L., et al. Biol. Reprod. 82(2):459-468(2010)
Kokubo, M., et al. J. Neurosci. 29(28):8901-8913(2009)
Anderson, K.A., et al. Cell Metab. 7(5):377-388(2008)
Park, C.S., et al. Neuroscience 151(1):43-55(2008)
Hoyer-Hansen, M., et al. Mol. Cell 25(2):193-205(2007)
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