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VAPB Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O95292 |
| Other Accession | A5GFS8, A2VDZ9 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Pig |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | H=27;M=27;Rat=27 KDa |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 9217 |
|---|---|
| Antigen Region | 126-139 aa |
| Other Names | Vesicle-associated membrane protein-associated protein B/C, VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C, VAPB |
| Dilution | WB~~1:1000 |
| Target/Specificity | This VAPB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 126-139 amino acids from the Central region of human VAPB. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VAPB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VAPB (HGNC:12649) |
|---|---|
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). Interacts with STARD3 in a FFAT motif phosphorylation dependent manner (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity (PubMed:16891305, PubMed:20940299). Involved in cellular calcium homeostasis regulation (PubMed:22131369). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9P0L0}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane |
| Tissue Location | Ubiquitous. Isoform 1 predominates. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
References
Nishimura Y.,et al.Biochem. Biophys. Res. Commun. 254:21-26(1999).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 414:865-871(2001).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
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