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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   B cell receptor signaling   >   FITC Anti-Human CD19 (SJ25C1) Antibody   

FITC Anti-Human CD19 (SJ25C1) Antibody

     
  • FC - FITC Anti-Human CD19 (SJ25C1) Antibody ATB10446-T025
    Human peripheral blood lymphocytes were stained with 5 uL (0.125 ug) FITC Anti-Human CD19 (ATB10446) (solid line) or 0.125 ug FITC Mouse IgG1 isotype control (dashed line).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC
Isotype Mouse IgG1, kappa
Concentration 5 µL (0.125 µg)/test
Reactivity Human
Formulation 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Additional Information
Gene ID 930
Gene Name CD19
Alternative Name(s) Leu-12, B4
Format FITC
Storage Conditions 2-8°C protected from light
Research Areas
Piatosa B, Birbach M, Siewiera K, Ussowicz M, Kalwak K, Drabko K, Rekawek A, Tkaczyk K, Kurowski PN. 2013. Cytometry Part B. 84B: 179–186. (Flow Cytometry) Sekiguchi DR, Smith SB, Sutter JA, Goodman NG, Propert K, Louzoun Y, Rogers W, Luning Prak ET. 2011. Cytometry Part B. 80B: 291–299. (Flow Cytometry) Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. B-cell antigens: CD19. In: Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:34-36. (Flow Cytometry) Karahan GE, Eikmans M, Anholts JDH, Class FHJ and Heidt S. 2014. Clin Exp Immunol. 177(1): 333-340. (Flow Cytometry) Bansal RR, Mackay CR, Moser B and Ebert M. 2012. Eur J Immunol. 42(1): 110-119. (Flow Cytometry) Jourdan M, Caraux A, Caron G, Robert N, Fiol G, Rème T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, De Vos J, Kassambara A, Duperray C, Hose D, Fest T, Tarte K and Klein B. 2011. J Immunol. 187(8): 3931-3941. (Flow Cytometry) Goval J-J, Greimers R, Boniver J and de Leval L. 2006. J Histochem Cytochem. 54(1): 75-84. (Immunofluorescence – frozen tissue)

Background

The SJ25C1 antibody reacts with human CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 (CR2), CD81 (TAPA-1) and CD225 (Leu13), in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. Upon activation and tyrosine phosphorylation, the CD19 molecule can provide an anchor for cytoplasmic signaling proteins such as GRB2, SOS or PLCG2. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells. The SJ25C1 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets

References

Piatosa B, Birbach M, Siewiera K, Ussowicz M, Kalwak K, Drabko K, Rekawek A, Tkaczyk K, Kurowski PN. 2013. Cytometry Part B. 84B: 179–186. (Flow Cytometry)

Sekiguchi DR, Smith SB, Sutter JA, Goodman NG, Propert K, Louzoun Y, Rogers W, Luning Prak ET. 2011. Cytometry Part B. 80B: 291–299. (Flow Cytometry)

Dörken B, Möller P, Pezzutto A, Schwartz-Albiez R, Moldenhauer G. B-cell antigens: CD19. In: Knapp W, Dörken B, Gilks WR, et al, ed. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:34-36. (Flow Cytometry)

Karahan GE, Eikmans M, Anholts JDH, Class FHJ and Heidt S. 2014. Clin Exp Immunol. 177(1): 333-340. (Flow Cytometry)

Bansal RR, Mackay CR, Moser B and Ebert M. 2012. Eur J Immunol. 42(1): 110-119. (Flow Cytometry)

Jourdan M, Caraux A, Caron G, Robert N, Fiol G, Rème T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, De Vos J, Kassambara A, Duperray C, Hose D, Fest T, Tarte K and Klein B. 2011. J Immunol. 187(8): 3931-3941. (Flow Cytometry)

Goval J-J, Greimers R, Boniver J and de Leval L. 2006. J Histochem Cytochem. 54(1): 75-84. (Immunofluorescence – frozen tissue)

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$ 160.00
$ 720.00
Cat# ATB10446-T025
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