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YY1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant YY1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P25490 |
| Other Accession | NM_003403 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4C1 |
| Calculated MW | 44713 Da |
| Gene ID | 7528 |
|---|---|
| Other Names | Transcriptional repressor protein YY1, Delta transcription factor, INO80 complex subunit S, NF-E1, Yin and yang 1, YY-1, YY1, INO80S |
| Target/Specificity | YY1 (NP_003394, 221 a.a. ~ 320 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | YY1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
References
CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. de Nigris F, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660740.Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes. Inayoshi Y, et al. J Virol, 2010 Aug. PMID 20519390.Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Nassiri M, et al. Arterioscler Thromb Vasc Biol, 2010 Jul. PMID 20431063.Identification of Yin Yang 1-interacting partners at -1026C/A in the human iNOS promoter. Li W, et al. Arch Biochem Biophys, 2010 Jun 15. PMID 20430007.Identification of a Smad4/YY1-recognized and BMP2-responsive transcriptional regulatory module in the promoter of mouse GABA transporter subtype I (Gat1) gene. Yao M, et al. J Neurosci, 2010 Mar 17. PMID 20237276.
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