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WDR5 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant WDR5.

     
  • IF - WDR5 Antibody (monoclonal) (M01) AT4533a
    Immunofluorescence of monoclonal antibody to WDR5 on HeLa cell. [antibody concentration 10 ug/ml]
    detail
  • WB - WDR5 Antibody (monoclonal) (M01) AT4533a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.29 KDa) .
    detail
  • WB - WDR5 Antibody (monoclonal) (M01) AT4533a
    WDR5 monoclonal antibody (M01), clone 2C2. Western Blot analysis of WDR5 expression in A-549 ( (Cat # AT4533a )
    detail
  • WB - WDR5 Antibody (monoclonal) (M01) AT4533a
    WDR5 monoclonal antibody (M01), clone 2C2. Western Blot analysis of WDR5 expression in Hs 181.Tes.
    detail
  • E - WDR5 Antibody (monoclonal) (M01) AT4533a
    Detection limit for recombinant GST tagged WDR5 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession P61964
Other Accession NM_017588
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 2C2
Calculated MW 36588 Da
Additional Information
Gene ID 11091
Other Names WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3
Target/Specificity WDR5 (NP_060058, 16 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsWDR5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)
citation

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Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

References

A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Davis OS, et al. Behav Genet, 2010 Mar 21. PMID 20306291.PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Feng W, et al. Nat Struct Mol Biol, 2010 Apr. PMID 20208542.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Jin S, et al. J Clin Invest, 2010 Feb 1. PMID 20093773.Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8. Yates JA, et al. FEBS Lett, 2010 Feb 19. PMID 20085832.WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080758.

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$ 350.00
Cat# AT4533a
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Availability: 7-10 days
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