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WDR5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant WDR5.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P61964 |
| Other Accession | NM_017588 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2C2 |
| Calculated MW | 36588 Da |
| Gene ID | 11091 |
|---|---|
| Other Names | WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3 |
| Target/Specificity | WDR5 (NP_060058, 16 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | WDR5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
References
A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Davis OS, et al. Behav Genet, 2010 Mar 21. PMID 20306291.PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Feng W, et al. Nat Struct Mol Biol, 2010 Apr. PMID 20208542.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Jin S, et al. J Clin Invest, 2010 Feb 1. PMID 20093773.Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8. Yates JA, et al. FEBS Lett, 2010 Feb 19. PMID 20085832.WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080758.
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