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WBSCR1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant WBSCR1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15056 |
| Other Accession | NM_031992 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4B2 |
| Calculated MW | 27385 Da |
| Gene ID | 7458 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 4H, eIF-4H, Williams-Beuren syndrome chromosomal region 1 protein, EIF4H, KIAA0038, WBSCR1, WSCR1 |
| Target/Specificity | WBSCR1 (NP_114381.1, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | WBSCR1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.
References
Genome-wide searching of rare genetic variants in WTCCC data. Feng T, et al. Hum Genet, 2010 Sep. PMID 20549515.Detecting rare variants for complex traits using family and unrelated data. Zhu X, et al. Genet Epidemiol, 2010 Feb. PMID 19847924.Uncoupling stress granule assembly and translation initiation inhibition. Mokas S, et al. Mol Biol Cell, 2009 Jun. PMID 19369421.Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Marintchev A, et al. Cell, 2009 Feb 6. PMID 19203580.Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. Rozovsky N, et al. RNA, 2008 Oct. PMID 18719248.
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