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VPREB3 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant VPREB3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UKI3 |
| Other Accession | NM_013378 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4H8 |
| Calculated MW | 13710 Da |
| Gene ID | 29802 |
|---|---|
| Other Names | Pre-B lymphocyte protein 3, N27C7-2, Protein VPreB3, VPREB3 |
| Target/Specificity | VPREB3 (NP_037510, 24 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | VPREB3 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.
References
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript. Rangel R, et al. J Biol Chem, 2005 May 6. PMID 15757909.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802.Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. Rosnet O, et al. J Biol Chem, 2004 Mar 12. PMID 14670953.
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