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VCL Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant VCL.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | P18206 |
| Other Accession | BC039174 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2C6-1B5 |
| Calculated MW | 123799 Da |
| Gene ID | 7414 |
|---|---|
| Other Names | Vinculin, Metavinculin, MV, VCL |
| Target/Specificity | VCL (AAH39174.1, 1 a.a. ~ 1066 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | VCL Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
References
1.Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig.Maghdessian R, Cote F, Rouleau T, Ouadda AB, Levy E, Lavoie JC.J Pharmacol Exp Ther. 2010 Apr 7. [Epub ahead of print]
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