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TRIM63 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TRIM63.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q969Q1 |
| Other Accession | NM_032588 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6G6 |
| Calculated MW | 40248 Da |
| Gene ID | 84676 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM63, 632-, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, TRIM63, IRF, MURF1, RNF28, SMRZ |
| Target/Specificity | TRIM63 (NP_115977, 254 a.a. ~ 352 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TRIM63 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
References
Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling? Conraads VM, et al. Basic Res Cardiol, 2010 Mar. PMID 19859778.Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Mearini G, et al. Cardiovasc Res, 2010 Jan 15. PMID 19850579.Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. L?ger B, et al. Muscle Nerve, 2009 Jul. PMID 19533653.Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold. Mrosek M, et al. Biochemistry, 2008 Oct 7. PMID 18795805.The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Waddell DS, et al. Am J Physiol Endocrinol Metab, 2008 Oct. PMID 18612045.
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