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SUFU Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant SUFU.

     
  • E - SUFU Antibody (monoclonal) (M01) AT4102a
    Detection limit for recombinant GST tagged SUFU is approximately 0.1ng/ml as a capture antibody.
    detail
  •  - SUFU Antibody (monoclonal) (M01) AT4102a
    Proximity Ligation Analysis of protein-protein interactions between STK36 and SUFU HeLa cells were stained with anti-STK36 rabbit purified polyclonal 1:1200 and anti-SUFU mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession Q9UMX1
Other Accession BC013291
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1B2
Calculated MW 53947 Da
Additional Information
Gene ID 51684
Other Names Suppressor of fused homolog, SUFUH, SUFU
Target/Specificity SUFU (AAH13291, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSUFU Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

References

Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. Brugi?res L, et al. J Med Genet, 2010 Feb. PMID 19833601.Identification of a SUFU germline mutation in a family with Gorlin syndrome. Pastorino L, et al. Am J Med Genet A, 2009 Jul. PMID 19533801.Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium. Kim KH, et al. Pathol Int, 2009 May. PMID 19432668.Role and regulation of human tumor suppressor SUFU in Hedgehog signaling. Cheng SY, et al. Adv Cancer Res, 2008. PMID 19055941.MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Pizzimenti S, et al. Free Radic Biol Med, 2009 Jan 15. PMID 19022373.

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$ 350.00
Cat# AT4102a
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Availability: 7-10 days
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