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STAT4 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant STAT4.

     
  • IF - STAT4 Antibody (monoclonal) (M01) AT4063a
    Immunofluorescence of monoclonal antibody to STAT4 on HeLa cell. [antibody concentration 10 ug/ml]
    detail
  • IP - STAT4 Antibody (monoclonal) (M01) AT4063a
    Immunoprecipitation of STAT4 transfected lysate using anti-STAT4 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with STAT4 MaxPab rabbit polyclonal antibody.
    detail
  • WB - STAT4 Antibody (monoclonal) (M01) AT4063a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (108.02 KDa) .
    detail
  • WB - STAT4 Antibody (monoclonal) (M01) AT4063a
    STAT4 monoclonal antibody (M01), clone 1C2-1C12. Western Blot analysis of STAT4 expression in human liver.
    detail
  • WB - STAT4 Antibody (monoclonal) (M01) AT4063a
    STAT4 monoclonal antibody (M01), clone 1C2-1C12 Western Blot analysis of STAT4 expression in A-549 ( (Cat # AT4063a )
    detail
  • WB - STAT4 Antibody (monoclonal) (M01) AT4063a
    Western Blot analysis of STAT4 expression in transfected 293T cell line by STAT4 monoclonal antibody (M01), clone 1C2-1C12.

    Lane 1: STAT4 transfected lysate(85.9 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • IHC - STAT4 Antibody (monoclonal) (M01) AT4063a
    Immunoperoxidase of monoclonal antibody to STAT4 on formalin-fixed paraffin-embedded human ovary, clear cell carcinoma tissue. [antibody concentration 1 ~ 10 ug/ml]
    detail
  • E - STAT4 Antibody (monoclonal) (M01) AT4063a
    Detection limit for recombinant GST tagged STAT4 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, IP, E
Primary Accession Q14765
Other Accession BC031212
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1C2-1C12
Calculated MW 85941 Da
Additional Information
Gene ID 6775
Other Names Signal transducer and activator of transcription 4, STAT4
Target/Specificity STAT4 (AAH31212, 1 a.a. ~ 748 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSTAT4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

References

STAT4 is a confirmed genetic risk factor for Sj?gren's syndrome and could be involved in type 1 interferon pathway signaling. Gestermann N, et al. Genes Immun, 2010 Jul. PMID 20535138.Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Plant D, et al. Ann Rheum Dis, 2010 Aug. PMID 20498205.Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap. Vuong MT, et al. PLoS One, 2010 May 10. PMID 20479942.Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. Glas J, et al. PLoS One, 2010 Apr 29. PMID 20454450.

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$ 350.00
Cat# AT4063a
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