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SSB Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant SSB.

     
  • WB - SSB Antibody (monoclonal) (M01) AT4042a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (70.62 KDa) .
    detail
  • WB - SSB Antibody (monoclonal) (M01) AT4042a
    SSB monoclonal antibody (M01), clone 1D6-H5 Western Blot analysis of SSB expression in HL-60 ( (Cat # AT4042a )
    detail
  • IHC - SSB Antibody (monoclonal) (M01) AT4042a
    Immunoperoxidase of monoclonal antibody to SSB on formalin-fixed paraffin-embedded human tonsil tissue. [antibody concentration 5 ug/ml]
    detail
  • E - SSB Antibody (monoclonal) (M01) AT4042a
    Detection limit for recombinant GST tagged SSB is 10 ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P05455
Other Accession BC001289
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 1D6-H5
Calculated MW 46837 Da
Additional Information
Gene ID 6741
Other Names Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB
Target/Specificity SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSSB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
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Background

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).

References

1.Phosphorylation of human La protein at Ser366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.Tang J, Zhang ZH, Huang M, Heise T, Zhang J, Liu GL.Journal of Viral Hepatitis, 2012 doi:10.1111/ j.1365-2893.2012.01636.x2.Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.Brenet F, Socci ND, Sonenberg N, Holland EC.Oncogene. 2009 Jan 8;28(1):128-39. Epub 2008 Oct 6.

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$ 350.00
Cat# AT4042a
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