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SOX8 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SOX8.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57073 |
| Other Accession | NM_014587 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5A7 |
| Calculated MW | 47314 Da |
| Gene ID | 30812 |
|---|---|
| Other Names | Transcription factor SOX-8, SOX8 |
| Target/Specificity | SOX8 (NP_055402, 102 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SOX8 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
References
Differential expression of SOX2 and SOX17 in testicular germ cell tumors. Nonaka D. Am J Clin Pathol, 2009 May. PMID 19369635.Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. Hoff S, et al. J Comp Neurol, 2008 Aug 1. PMID 18512230.The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissm?ller S, et al. Nucleic Acids Res, 2006. PMID 16582099.The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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