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SNCB Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a full-length recombinant SNCB.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16143 |
| Other Accession | BC002902 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3H4 |
| Calculated MW | 14288 Da |
| Gene ID | 6620 |
|---|---|
| Other Names | Beta-synuclein, SNCB |
| Target/Specificity | SNCB (AAH02902, 1 a.a. ~ 134 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SNCB Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
References
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Nishioka K, et al. Arch Neurol, 2010 Aug. PMID 20697047.Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. Ye Q, et al. Oncol Rep, 2010 Feb. PMID 20043104.Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Rivers RC, et al. Protein Sci, 2008 May. PMID 18436957.Spectroscopic and functional characterization of human beta-synuclein. Lee J, et al. Protein Pept Lett, 2007. PMID 18221001.An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid. Salem SA, et al. Brain Res, 2007 Sep 19. PMID 17692832.
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