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SLC11A2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant SLC11A2.

     
  • WB - SLC11A2 Antibody (monoclonal) (M01) AT3900a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (32.89 KDa) .
    detail
  • IHC - SLC11A2 Antibody (monoclonal) (M01) AT3900a
    Immunoperoxidase of monoclonal antibody to SLC11A2 on formalin-fixed paraffin-embedded human endometrium cancer. [antibody concentration 3 ug/ml]
    detail
  • E - SLC11A2 Antibody (monoclonal) (M01) AT3900a
    Detection limit for recombinant GST tagged SLC11A2 is 0.03 ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P49281
Other Accession NM_000617
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4C6
Calculated MW 62266 Da
Additional Information
Gene ID 4891
Other Names Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, DCT1, DMT1, NRAMP2
Target/Specificity SLC11A2 (NP_000608, 1 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSLC11A2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
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Background

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

References

1.Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra.Montalbetti N, Simonin A, Dalghi MG, Kovacs G, Hediger MAJ Biomol Screen. 2014 Feb 6.2.Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS.Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15489-94. Epub 2009 Aug 25.3.Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.Blood. 2008 Nov 15;112(10):4268-75. Epub 2008 Sep 5.

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$ 350.00
Cat# AT3900a
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Availability: 7-10 days
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