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SIX3 Antibody (monoclonal) (M10)
Mouse monoclonal antibody raised against a full length recombinant SIX3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O95343 |
| Other Accession | NM_005413 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 4H6 |
| Calculated MW | 35487 Da |
| Gene ID | 6496 |
|---|---|
| Other Names | Homeobox protein SIX3, Sine oculis homeobox homolog 3, SIX3 |
| Target/Specificity | SIX3 (NP_005404, 273 a.a. ~ 332 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SIX3 Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
References
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Human variation in alcohol response is influenced by variation in neuronal signaling genes. Joslyn G, et al. Alcohol Clin Exp Res, 2010 May. PMID 20201926.Heterozygous mutations in SIX3 and SHH are associated with schizencephaly and further expand the clinical spectrum of holoprosencephaly. Hehr U, et al. Hum Genet, 2010 Mar. PMID 20157829.Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma. Zhang X, et al. Mol Vis, 2009 Dec 27. PMID 20057906.Absence of SIX3 mutations in patients with congenital hypopituitarism. Gaston-Massuet C, et al. Am J Med Genet A, 2009 Dec. PMID 19921650.
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