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RBAF600 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RBAF600.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q5T4S7 |
| Other Accession | NM_020765 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2D12 |
| Calculated MW | 573841 Da |
| Gene ID | 23352 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase UBR4, 632-, 600 kDa retinoblastoma protein-associated factor, N-recognin-4, Retinoblastoma-associated factor of 600 kDa, RBAF600, p600, Zinc finger UBR1-type protein 1, UBR4, KIAA0462, KIAA1307, RBAF600, ZUBR1 |
| Target/Specificity | RBAF600 (NP_065816, 94 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RBAF600 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Lennerz V, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16247014.p600, a unique protein required for membrane morphogenesis and cell survival. Nakatani Y, et al. Proc Natl Acad Sci U S A, 2005 Oct 18. PMID 16214886.Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Huh KW, et al. Proc Natl Acad Sci U S A, 2005 Aug 9. PMID 16061792.
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