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NR3C1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NR3C1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P04150 |
| Other Accession | BC015610 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2C8 |
| Calculated MW | 85659 Da |
| Gene ID | 2908 |
|---|---|
| Other Names | Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL |
| Target/Specificity | NR3C1 (AAH15610, 51 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NR3C1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
References
Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Sarzynski MA, et al. Int J Obes (Lond), 2010 Aug 24. PMID 20733583.Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. Desrivi?res S, et al. Addict Biol, 2010 Aug 23. PMID 20731635.Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis. van Oosten MJ, et al. Arthritis Res Ther, 2010. PMID 20727199.Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients. Mwinyi J, et al. World J Gastroenterol, 2010 Aug 21. PMID 20712049.Genetic Predictors of Glucocorticoid Response in Pediatric Patients With Inflammatory Bowel Diseases. De Iudicibus S, et al. J Clin Gastroenterol, 2010 Aug 6. PMID 20697295.
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