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MYCN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MYCN.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P04198 |
| Other Accession | NM_005378 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3H4 |
| Calculated MW | 49561 Da |
| Gene ID | 4613 |
|---|---|
| Other Names | N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC |
| Target/Specificity | MYCN (NP_005369, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MYCN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
References
Analysis of the REL, BCL11A, and MYCN proto-oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia. Deambrogi C, et al. Am J Hematol, 2010 Jul. PMID 20575024.Pleiotropic role for MYCN in medulloblastoma. Swartling FJ, et al. Genes Dev, 2010 May 15. PMID 20478998.Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. Muth D, et al. Cancer Res, 2010 May 1. PMID 20424123.MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Foley NH, et al. Mol Cancer, 2010 Apr 21. PMID 20409325.Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. Williams RD, et al. Clin Cancer Res, 2010 Apr 1. PMID 20332316.
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