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MEOX2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant MEOX2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | P50222 |
| Other Accession | BC017021 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5A6 |
| Calculated MW | 33594 Da |
| Gene ID | 4223 |
|---|---|
| Other Names | Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2 |
| Target/Specificity | MEOX2 (AAH17021, 1 a.a. ~ 303 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MEOX2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor. Ohshima J, et al. Genes Chromosomes Cancer, 2009 Dec. PMID 19760604.Functional role of Meox2 during the epithelial cytostatic response to TGF-beta. Valcourt U, et al. Mol Oncol, 2007 Jun. PMID 19383287.A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. Irelan JT, et al. PLoS One, 2009. PMID 19340300.Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Chen Y, et al. Blood, 2008 Feb 1. PMID 17957028.
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