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KLF1 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant KLF1.

     
  • WB - KLF1 Antibody (monoclonal) (M05) AT2626a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (31.79 KDa) .
    detail
  • WB - KLF1 Antibody (monoclonal) (M05) AT2626a
    Western Blot analysis of KLF1 expression in transfected 293T cell line by KLF1 monoclonal antibody (M05), clone 2A6.

    Lane 1: KLF1 transfected lysate (Predicted MW: 38.2 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - KLF1 Antibody (monoclonal) (M05) AT2626a
    Detection limit for recombinant GST tagged KLF1 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13351
Other Accession NM_006563
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG3 Kappa
Clone Names 2A6
Calculated MW 38221 Da
Additional Information
Gene ID 10661
Other Names Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
Target/Specificity KLF1 (NP_006554, 183 a.a. ~ 237 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsKLF1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

References

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Borg J, et al. Nat Genet, 2010 Sep. PMID 20676099.KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Zhou D, et al. Nat Genet, 2010 Sep. PMID 20676097.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Ganesh SK, et al. Nat Genet, 2009 Nov. PMID 19862010.Distinct modes of gene regulation by a cell-specific transcriptional activator. Sengupta T, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19251649.

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$ 350.00
Cat# AT2626a
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Availability: 7-10 days
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