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IRAK1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant IRAK1.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, IP, E |
|---|---|
| Primary Accession | P51617 |
| Other Accession | BC054000 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3F7 |
| Calculated MW | 76537 Da |
| Gene ID | 3654 |
|---|---|
| Other Names | Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1, IRAK |
| Target/Specificity | IRAK1 (AAH54000, 530 a.a. ~ 693 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | IRAK1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Molecular mechanism underlying the inflammatory complication of leptin in macrophages. Vaughan T, et al. Mol Immunol, 2010 Sep. PMID 20619458.The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. Chatzikyriakidou A, et al. Scand J Immunol, 2010 May. PMID 20500689.Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Abu-Maziad A, et al. Pediatr Res, 2010 Oct. PMID 20463618.Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Potter C, et al. Ann Rheum Dis, 2010 Jul. PMID 20448286.
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