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HLA-DPB1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HLA-DPB1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IP, E |
|---|---|
| Primary Accession | P04440 |
| Other Accession | BC013184 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6C6 |
| Calculated MW | 29159 Da |
| Gene ID | 3115 |
|---|---|
| Other Names | HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B |
| Target/Specificity | HLA-DPB1 (AAH13184, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HLA-DPB1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
References
Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity. Ovsyannikova IG, et al. PLoS One, 2010 Jul 27. PMID 20668555.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Mychaleckyj JC, et al. Clin Trials, 2010. PMID 20595243.Anthropological analysis of Koreans using HLA class II diversity among East Asians. Yang JH, et al. Tissue Antigens, 2010 May 26. PMID 20522202.[Association of regulatory region of HLA-DPB1 with nasopharyngeal carcinoma in southern Chinese Hans] Wang P, et al. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2010 Mar. PMID 20518290.
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