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GNG3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GNG3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P63215 |
| Other Accession | BC015563 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 1E10-1B5 |
| Calculated MW | 8305 Da |
| Gene ID | 2785 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3, GNG3, GNGT3 |
| Target/Specificity | GNG3 (AAH15563, 1 a.a. ~ 75 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GNG3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004 [PubMed 15314181]).
References
Regulation of Golgi structure and secretion by receptor-induced G protein betagamma complex translocation. Saini DK, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534534.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Mice with deficiency of G protein gamma3 are lean and have seizures. Schwindinger WF, et al. Mol Cell Biol, 2004 Sep. PMID 15314181.Characterization of heterotrimeric G protein complexes in rice plasma membrane. Kato C, et al. Plant J, 2004 Apr. PMID 15078334.Glucagon and regulation of glucose metabolism. Jiang G, et al. Am J Physiol Endocrinol Metab, 2003 Apr. PMID 12626323.
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