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GALT Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GALT.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P07902 |
| Other Accession | BC015045 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 4C11 |
| Calculated MW | 43363 Da |
| Gene ID | 2592 |
|---|---|
| Other Names | Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase, GALT |
| Target/Specificity | GALT (AAH15045, 1 a.a. ~ 379 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GALT Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined.
References
Molecular and biochemical characterization of the GALT gene in Korean patients with galactose-1-phosphate uridyltransferase deficiency. Ko DH, et al. Clin Chim Acta, 2010 Oct 9. PMID 20547145.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Classical galactosemia in Estonia: selective neonatal screening, incidence, and genotype/phenotype data of diagnosed patients. Ounap K, et al. J Inherit Metab Dis, 2010 Apr. PMID 20151200.Analysis of galactosemia-linked mutations of GALT enzyme using a computational biology approach. Facchiano A, et al. Protein Eng Des Sel, 2010 Feb. PMID 20008339.Galactose-1-phosphate uridyl transferase deficiency is not associated with M?llerian aplasia in Dutch patients. Nijland R, et al. J Pediatr Adolesc Gynecol, 2009 Aug. PMID 19646668.
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