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G3BP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant G3BP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q13283 |
| Other Accession | BC006997 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F3 |
| Calculated MW | 52164 Da |
| Gene ID | 10146 |
|---|---|
| Other Names | Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA helicase VIII, hDH VIII, GAP SH3 domain-binding protein 1, G3BP1, G3BP |
| Target/Specificity | G3BP (AAH06997, 214 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | G3BP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
References
1.5-Fluorouracil affects assembly of stress granules based on RNA incorporation.Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch SNucleic Acids Res. 2014 Apr 11.2.Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons.Martin S, Zekri L, Metz A, Maurice T, Chebli K, Vignes M, Tazi JJ Neurochem. 2013 Feb 4. doi: 10.1111/jnc.12189.3.Progressive loss of dopaminergic neurons induced by unilateral rotenone infusion into the medial forebrain bundle.Norazit A, Meedeniya AC, Nguyen MN, Mackay-Sim A.Brain Res. 2010 Aug 28. [Epub ahead of print]
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