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G22P1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant XRCC6.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | P12956 |
| Other Accession | BC008343 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 4C2-1A6 |
| Calculated MW | 69843 Da |
| Gene ID | 2547 |
|---|---|
| Other Names | X-ray repair cross-complementing protein 6, 364-, 4299-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, XRCC6, G22P1 |
| Target/Specificity | XRCC6 (AAH08343.1, 1 a.a. ~ 609 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | G22P1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
References
1.DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer.Bouchaert P, Guerif S, Debiais C, Irani J, Fromont G.Int J Radiat Oncol Biol Phys. 2012 Apr 10. [Epub ahead of print]2.Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks.Nishii M, Nakano S, Nakamura S, Wate R, Shinde A, Kaneko S, Kusaka H.Neuromuscul Disord. 2011 Feb 23. [Epub ahead of print]
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