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FMR1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant FMR1.

     
  • WB - FMR1 Antibody (monoclonal) (M01) AT2078a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
    detail
  • WB - FMR1 Antibody (monoclonal) (M01) AT2078a
    FMR1 monoclonal antibody (M01), clone 2D4 Western Blot analysis of FMR1 expression in HepG2 ( (Cat # AT2078a )
    detail
  • WB - FMR1 Antibody (monoclonal) (M01) AT2078a
    Western Blot analysis of FMR1 expression in transfected 293T cell line by FMR1 monoclonal antibody (M01), clone 2D4.

    Lane 1: FMR1 transfected lysate(34.1 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • WB - FMR1 Antibody (monoclonal) (M01) AT2078a
    Western blot analysis of FMR1 over-expressed 293 cell line, cotransfected with FMR1 Validated Chimera RNAi ( (Cat # AT2078a )
    detail
  • E - FMR1 Antibody (monoclonal) (M01) AT2078a
    Detection limit for recombinant GST tagged FMR1 is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q06787
Other Accession NM_002024
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2D4
Calculated MW 71174 Da
Additional Information
Gene ID 2332
Other Names Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1
Target/Specificity FMR1 (NP_002015, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFMR1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

References

An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis. Chen L, et al. J Mol Diagn, 2010 Sep. PMID 20616364.Genetic diversity of the fragile X syndrome gene (FMR1) in a large Sub-Saharan West African population. Peprah EK, et al. Ann Hum Genet, 2010 Jul. PMID 20597902.An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS). Hashimoto RI, et al. J Psychiatr Res, 2010 May 26. PMID 20537351.hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Lee EK, et al. Nat Struct Mol Biol, 2010 Jun. PMID 20473314.A simple, high-throughput assay for Fragile X expanded alleles using triple repeat primed PCR and capillary electrophoresis. Lyon E, et al. J Mol Diagn, 2010 Jul. PMID 20431035.

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$ 350.00
Cat# AT2078a
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Availability: 7-10 days
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