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FIS1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full-length recombinant FIS1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3D6 |
| Other Accession | BC003540 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3G6 |
| Calculated MW | 16938 Da |
| Gene ID | 51024 |
|---|---|
| Other Names | Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11 |
| Target/Specificity | FIS1 (AAH03540.1, 1 a.a. ~ 152 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FIS1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).
References
Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells. Kaddour-Djebbar I, et al. Int J Oncol, 2010 Jun. PMID 20428767.Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. Mai S, et al. J Cell Sci, 2010 Mar 15. PMID 20179104.Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. Serasinghe MN, et al. J Biol Chem, 2010 Jan 1. PMID 19864424.The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Serasinghe MN, et al. Exp Cell Res, 2008 Nov 15. PMID 18845145.Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. Park KS, et al. J Biol Chem, 2008 Nov 28. PMID 18832378.
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