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FCN1 Antibody (monoclonal) (M06)

Mouse monoclonal antibody raised against a partial recombinant FCN1.

     
  • WB - FCN1 Antibody (monoclonal) (M06) AT2029a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
    detail
  • WB - FCN1 Antibody (monoclonal) (M06) AT2029a
    Western Blot analysis of FCN1 expression in transfected 293T cell line by FCN1 monoclonal antibody (M06), clone 2B7.

    Lane 1: FCN1 transfected lysate(35.1 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - FCN1 Antibody (monoclonal) (M06) AT2029a
    Detection limit for recombinant GST tagged FCN1 is approximately 0.3ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00602
Other Accession NM_002003
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2B7
Calculated MW 35078 Da
Additional Information
Gene ID 2219
Other Names Ficolin-1, Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin, FCN1, FCNM
Target/Specificity FCN1 (NP_001994, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFCN1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

References

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. Honor? C, et al. J Leukoc Biol, 2010 Jul. PMID 20400674.Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. Wittenborn T, et al. J Innate Immun, 2010 Feb. PMID 20375634.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. Gout E, et al. J Biol Chem, 2010 Feb 26. PMID 20032467.Binding site of C-reactive protein on M-ficolin. Tanio M, et al. Mol Immunol, 2009 Dec. PMID 19853918.

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$ 350.00
Cat# AT2029a
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Availability: 7-10 days
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