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FAP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant FAP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP, E |
|---|---|
| Primary Accession | Q12884 |
| Other Accession | BC026250 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1E6 |
| Calculated MW | 87713 Da |
| Gene ID | 2191 |
|---|---|
| Other Names | Prolyl endopeptidase FAP, 170 kDa melanoma membrane-bound gelatinase, Dipeptidyl peptidase FAP, Fibroblast activation protein alpha, FAPalpha, Serine integral membrane protease, SIMP, Surface-expressed protease, Seprase, Antiplasmin-cleaving enzyme FAP, soluble form, APCE, 3421-, FAP (HGNC:3590) |
| Target/Specificity | FAP (AAH26250, 525 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FAP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
References
1.Fibroblast Activation Protein (FAP) Is Essential for the Migration of Bone Marrow Mesenchymal Stem Cells through RhoA Activation.Chung KM, Hsu SC, Chu YR, Lin MY, Jiaang WT, Chen RH, Chen XPLoS One. 2014 Feb 13;9(2):e88772. doi: 10.1371/journal.pone.0088772. eCollection 2014.2.Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment.Bohonowych J, Hance M, Nolan K, Defee M, Parsons C, Isaacs JProstate. 2013 Dec 16. doi: 10.1002/pros.22761.3.Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion.Denys H, Derycke L, Hendrix A, Westbroek W, Gheldof A, Narine K, Pauwels P, Gespach C, Bracke M, De Wever O.Cancer Lett. 2008 Aug 8;266(2):263-74.4.Fibroblast activation protein and chronic liver disease.Wang XM, Yao TW, Nadvi NA, Osborne B, McCaughan GW, Gorrell MD.Front Biosci. 2008 Jan 1;13:3168-80.
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