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F3 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant F3.

     
  • IP - F3 Antibody (monoclonal) (M01) AT1979a
    Immunoprecipitation of F3 transfected lysate using anti-F3 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with F3 MaxPab rabbit polyclonal antibody.
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  • WB - F3 Antibody (monoclonal) (M01) AT1979a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
    detail
  • WB - F3 Antibody (monoclonal) (M01) AT1979a
    F3 monoclonal antibody (M01), clone 4G4 Western Blot analysis of F3 expression in A-431 ( (Cat # AT1979a )
    detail
  • WB - F3 Antibody (monoclonal) (M01) AT1979a
    F3 monoclonal antibody (M01), clone 4G4. Western Blot analysis of F3 expression in Jurkat.
    detail
  • WB - F3 Antibody (monoclonal) (M01) AT1979a
    Western Blot analysis of F3 expression in transfected 293T cell line by F3 monoclonal antibody (M01), clone 4G4.

    Lane 1: F3 transfected lysate(33.1 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - F3 Antibody (monoclonal) (M01) AT1979a
    Detection limit for recombinant GST tagged F3 is approximately 0.03ng/ml as a capture antibody.
    detail
  •  - F3 Antibody (monoclonal) (M01) AT1979a
    Proximity Ligation Analysis of protein-protein interactions between F7 and F3. HeLa cells were stained with anti-F7 rabbit purified polyclonal 1:1200 and anti-F3 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IP, E
Primary Accession P13726
Other Accession BC011029
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4G4
Calculated MW 33068 Da
Additional Information
Gene ID 2152
Other Names Tissue factor, TF, Coagulation factor III, Thromboplastin, CD142, F3
Target/Specificity F3 (AAH11029, 45 a.a. ~ 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsF3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

References

No evidence for tissue factor on platelets. Bouchard BA, et al. Blood, 2010 Aug 5. PMID 20688968.A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Romero R, et al. Am J Obstet Gynecol, 2010 May. PMID 20452482.Predictive value of tissue factor bearing microparticles in cancer associated thrombosis. Zwicker JI. Thromb Res, 2010 Apr. PMID 20434015.

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$ 350.00
Cat# AT1979a
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