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DHX9 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DHX9.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q08211 |
| Other Accession | NM_001357 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3G7 |
| Calculated MW | 140958 Da |
| Gene ID | 1660 |
|---|---|
| Other Names | ATP-dependent RNA helicase A, RHA, DEAH box protein 9, Leukophysin, LKP, Nuclear DNA helicase II, NDH II, DHX9, DDX9, LKP, NDH2 |
| Target/Specificity | DHX9 (NP_001348, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DHX9 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.
References
1.Roles of the Linker Region of RNA Helicase A in HIV-1 RNA Metabolism.Xing L, Niu M, Zhao X, Kleiman LPLoS One. 2013 Nov 6;8(11):e78596. doi: 10.1371/journal.pone.0078596.2.Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing.Tsai PL, Chiou NT, Kuss S, Garcia-Sastre A, Lynch KW, Fontoura BMPLoS Pathog. 2013 Jun;9(6):e1003460. doi: 10.1371/journal.ppat.1003460. Epub 2013 Jun 27.3.In vitro and in vivo analysis of the interaction between RNA helicase A and HIV-1 RNA.Xing L, Niu M, Kleiman L.J Virol. 2012 Sep 26. [Epub ahead of print]4.Coordinate roles of Gag and RNA helicase A in promoting the annealing of tRNALys3 to HIV-1 RNA.Xing L, Liang C, Kleiman L.J Virol. 2010 Nov 24. [Epub ahead of print]5.Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells.Liu J, Song Y, Tian B, Qian J, Dong Y, Liu J, Liu B, Sun Z.J Biochem. 2010 Dec;148(6):659-67. Epub 2010 Sep 7.6.RNA Helicase A Interacts with RISC in Human Cells and Functions in RISC Loading.Robb GB, Rana TM.Mol Cell. 2007 May 25;26(4):523-37.
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