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COMMD1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant COMMD1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP, E |
|---|---|
| Primary Accession | Q8N668 |
| Other Accession | BC022046 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2A12 |
| Calculated MW | 21178 Da |
| Gene ID | 150684 |
|---|---|
| Other Names | COMM domain-containing protein 1, Protein Murr1, COMMD1, C2orf5, MURR1 |
| Target/Specificity | COMMD1 (AAH22046.1, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | COMMD1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).
References
1.Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1?.Schilling D, Bayer C, Li W, Molls M, Vaupel P, Multhoff G.PLoS One. 2012;7(2):e31110. Epub 2012 Feb 7.2.COMMD1-Mediated Ubiquitination Regulates CFTR Trafficking.Drevillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelievre A, Aissat A, Tarze A, Goossens M, Fanen P.PLoS One. 2011 Mar 31;6(3):e18334.3.Cu/Zn superoxide dismutase maturation and activity are regulated by COMMD1.Vonk WI, Wijmenga C, Berger R, van de Sluis B, Klomp LW.J Biol Chem. 2010 Jul 1. [Epub ahead of print]4.Copper-Induced Translocation of the Wilson Disease Protein ATP7B Independent of Murr1/COMMD1 and Rab7.Weiss KH, Lozoya JC, Tuma S, Gotthardt D, Reichert J, Ehehalt R, Stremmel W, Fullekrug J.Am J Pathol. 2008 Dec;173(6):1783-1794. Epub 2008 Oct 305.COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with PtdIns(4,5)p2.Burkhead JL, Morgan CT, Shinde U, Haddock G, Lutsenko S.J Biol Chem. 2009 Jan 2;284(1):696-707. Epub 2008 Oct 21.6.Tumor suppressor ARF promotes non-classic proteasomal independent polyubiquitination of COMMD1.Huang Y, Wu M, Li HY.J Biol Chem. 2008 Apr 25;283(17):11453-60. Epub 2008 Feb 27.7.Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.de Bie P, van de Sluis B, Burstein E, van de Berghe PV, Muller P, Berger R, Gitlin JD, Wijmenga C, Klomp LW.Gastroenterology. 2007 Oct;133(4):1316-26. Epub 2007 Jul 25.8.COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.Maine GN, Mao X, Komarck CM, Burstein E.EMBO J. 2007 Jan 24;26(2):436-47. Epub 2006 Dec 21.
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