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CNR2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CNR2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P34972 |
| Other Accession | NM_001841.1 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3C7 |
| Calculated MW | 39681 Da |
| Gene ID | 1269 |
|---|---|
| Other Names | Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B |
| Target/Specificity | CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CNR2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
References
1.Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity.Brocato B, Zoerner AA, Janjetovic Z, Skobowiat C, Gupta S, Moore Ii BM, Slominski A, Zhang J, Schenone M, Phinehas R, Ferry RJ Jr, Dick E Jr, Hubbard GB, Mari G, Schlabritz-Loutsevitch NPlacenta. 2013 Sep 2. pii: S0143-4004(13)00692-9. doi: 10.1016/j.placenta.2013.08.007.
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