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ATP2A3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ATP2A3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q93084 |
| Other Accession | BC035729 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2H3 |
| Calculated MW | 109256 Da |
| Gene ID | 489 |
|---|---|
| Other Names | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3, SERCA3, SR Ca(2+)-ATPase 3, Calcium pump 3, ATP2A3 |
| Target/Specificity | ATP2A3 (AAH35729, 501 a.a. ~ 620 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ATP2A3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
1.Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation.Arbabian A, Brouland JP, Apati A, Paszty K, Hegedus L, Enyedi A, Chomienne C, Papp B.FEBS J. 2012 Nov 15. doi: 10.1111/febs.12064.2.Expression of Sarco/Endoplasmic Reticulum Ca2+ATPase (SERCA) 3 proteins in two major conformational states in native human cell membranes.Corvazier E, Bredoux R, Kovacs T, Enouf J.Biochim Biophys Acta. 2009 Mar;1788(3):587-99. Epub 2008 Dec 16.
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