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Anti-Hemoglobin (MOUSE) Monoclonal Antibody
Hemoglobin Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Host | Mouse |
|---|---|
| Conjugate | Unconjugated |
| Target Species | Human |
| Reactivity | Human |
| Clonality | Monoclonal |
Application 
| WB, E, I, LCI |
| Application Note | Anti-Hemoglobin (whole molecule) (MOUSE) antibody has been tested by ELISA and western blot. This antibody is designed for use in lateral flow and western blot. Specific conditions of reactivity should be optimized by the end user. Expect a band of approximately 16 kDa. |
| Physical State | Liquid (sterile filtered) |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Immunogen | Anti-Hemoglobin (whole molecule) Monoclonal Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to amino acid residues near the N-terminus of Hb β-subunit conjugated to KLH. |
| Preservative | 0.01% (w/v) Sodium Azide |
| Purity | This protein A purified mouse monoclonal antibody reacts specifically with human Hemoglobin. Anti-Hemoglobin is purified from tissue culture supernatant by protein A purification. |
|---|---|
| Storage Condition | Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use. |
| Precautions Note | This product is for research use only and is not intended for therapeutic or diagnostic applications. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hemoglobin antibody detects the hemoglobin tetramer composed of alpha and beta subunits. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, and HbA-2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. Hemoglobin antibody reacts whole hemoglobin tetramer. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
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