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Anti-MIP-1α (RABBIT) Antibody
MIP-1 alpha Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Host | Rabbit |
|---|---|
| Conjugate | Unconjugated |
| Target Species | Human |
| Reactivity | Human |
| Clonality | Polyclonal |
Application 
| WB, E, I, LCI |
| Application Note | This antiserum against Human MIP-1a has been tested for use in ELISA of human MIP-1a found in cell supernatants or in plasma or serum. In ELISA formats and other immunoreactive assays, this antibody will recognize recombinant and native human MIP-1a present in body fluids and cell supernatants. This antiserum has not been evaluated for its ability to stain human MIP-1a in tissue sections, nor for its ability to neutralize human MIP-1a in bioassays, nor for its performance in immunoblot analysis. Reactivity in other immunoassays is unknown. |
| Physical State | Liquid (sterile filtered) |
| Immunogen | The whole rabbit serum was prepared by repeated immunizations with recombinant human MIP-1a produced in E.coli. |
| Preservative | 0.01% (w/v) Sodium Azide |
| Gene ID | 6348 |
|---|---|
| Other Names | 6348 |
| Purity | This antiserum has been heated to 56° C for 30 minutes. |
| Storage Condition | Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Precautions Note | This product is for research use only and is not intended for therapeutic or diagnostic applications. |
| Name | CCL3 |
|---|---|
| Synonyms | G0S19-1, MIP1A, SCYA3 |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
C-C motif chemokine 3, CCL3 or (MIP-1a) is a monokine with inflammatory and chemokinetic properties. CCL3 binds to CCR1, CCR4 and CCR5. It is one of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
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