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TAK1 Antibody
Rabbit Anti-Human TAK1 Polyclonal
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | O43318 |
| Other Accession | NP_003179.1 |
| Host | Rabbit |
| Reactivity | Rat |
| Clonality | Polyclonal |
| Format | TAK1 |
| Target/Specificity | TAK1 |
| Other Names | MAP3K7 Antibody, TAK1 Antibody, Mitogen-activated protein kinase kinase kinase 7 Antibody, TGF-beta-activated kinase 1 Antibody, Transforming growth factor-beta-activated kinase 1 Antibody, MEKK7 Antibody |
| Clone Names | TAK1 |
| Immunogen | Synthetic peptide of Human TAK1 (400-500 aa), conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Purification | Peptide Affinity Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:1000 dilution of SPC-736 was sufficient for detection of TAK1 in 15 µg of rat liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasm | Cell Membrane | Peripheral Membrane Protein | Cytoplasmic Side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TAK1 encoded by the gene MAP3K7, is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-β signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFκB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. TAK1 is important for TGF-β1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines.
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