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ULK1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | O75385 |
| Other Accession | NP_003556.1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Description | Rabbit Anti-Human ULK1 Polyclonal |
| Target/Specificity | Detects ~100 kDa. |
| Other Names | Unc-51 like kinase 1 (C. elegans) Antibody, Autophagy related protein 1 homolog Antibody, Autophagy-related protein 1 homolog Antibody, FLJ38455 Antibody, Serine/threonine-protein kinase ULK1 Antibody, Unc51.1 Antibody, ATG1A Antibody, UNC51, C. elegans, homolog of Antibody, EC:2.7.11.1 Antibody, Serine/threonine protein kinase Unc51.1 Antibody, FLJ46475 Antibody, ATG 1 Antibody, hATG1 Antibody, ATG1 Antibody, Unc-51-like kinase 1 Antibody, Serine/threonine protein kinase ULK1 Antibody, ULK1 Antibody, Unc 51 like kinase 1 Antibody, KIAA0722 Antibody, UNC 51 Antibody, ULK 1 Antibody, ULK1_HUMAN Antibody, UNC51 Antibody, Unc 51 (C. elegans) like kinase 1 Antibody, ATG1 autophagy related 1 homolog Antibody, |
| Immunogen | Synthetic peptide from the mid-protein of Human ULK1 (aa. 567-577) |
| Purification | Peptide Affinity Purified |
| Storage | -20ºC |
| Storage Buffer | PBS, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:1000 dilution of SPC-640 was sufficient for detection of ULK1 in 15 µg of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasm | Cytosol | Preautophagosomal Structure |
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Provided below are standard protocols that you may find useful for product applications.
Background
UNC-51 like kinase 1 (ULK1) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK1 is similar to ATG1, and it appears that both Atg1/ULK1 can bind to several ATG proteins regulating phosphorylation states and protein trafficking.
References
1. Okazaki N., et al. (2000) Brain Res Mol Brain Res. 85: 1-12.
2. Young A.R., et al. (2006) J Cell Sci. 119: 3888-900.
3. Kamada Y., et al. (2000) J Cell Biol. 150: 1507-13.
4. Lee S.B, et al. (2007) EMBO Rep. 8: 360-5.
5. Hara T., et al. (2008) J Cell Biol. 181: 497-510.
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