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UVRAG Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9P2Y5 |
| Other Accession | NP_003360.2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Description | Rabbit Anti-Human UVRAG Polyclonal |
| Target/Specificity | Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range. |
| Other Names | DHTX Antibody, p63 Antibody, UV radiation resistance associated Antibody, UVRAG_HUMAN Antibody |
| Immunogen | Synthetic peptide from the mid-protein of human UVRAG |
| Purification | Peptide Affinity Purified |
| Storage | -20ºC |
| Storage Buffer | PBS, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:1000 dilution of SPC-606 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
References
1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.
2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.
3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45.
4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
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