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TNF-R1 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IP, ICC |
|---|---|
| Primary Accession | P19438 |
| Other Accession | P19438 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Bovine, Dog |
| Clonality | Polyclonal |
| Description | Rabbit Anti-Mouse TNF-R1 Polyclonal |
| Target/Specificity | Detects ~55kDa. |
| Other Names | Tumor necrosis factor receptor 1 Antibody, TNFR-1 Antibody, TNFRSF1A Antibody, TNFAR Antibody, TNFR1 Antibody |
| Immunogen | Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues |
| Purification | Peptide Affinity Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 µg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Golgi Apparatus | Golgi Apparatus Membrane |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
References
1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34.
2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20.
3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
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